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Week 1 had a little bit of everything, with a few blowouts, a few thrillers, a few shocking upsets and a whole lot of Patrick Mahomes and Lamar Jackson. If we’re lucky, Week 2 will provide much of the same.

Injuries to Bosa and Thomas hobble 49ers defensive line.

A double dose of awful injury news for the San Francisco 49ers, who are already missing tight end George Kittle, cornerback Richard Sherman and defensive end Dee Ford. Within a span of three plays in the first quarter, two of their defensive linemen — Nick Bosa and Solomon Thomas — were carted off the field with knee injuries.

Bosa, last season’s top defensive rookie, appeared to injure his left knee while engaged with Jets tight end Trevon Wesco, who pushed him backward while finishing a block. Bosa’s leg bent at a weird angle, and after trying to get up, he went back down and waited for medical attention.

The 49ers announced that both Bosa and Thomas will not return Sunday. Without Bosa, Ford and Thomas, the 49ers’ best remaining pass-rushers are Kerry Hyder Jr. and Arik Armstead. Any extended absence for Bosa, who totaled 80 sacks, hurries and pressures for San Francisco last season, will seriously damage the 49ers’ chances of contending, let alone repeating as N.F.C. champions.

Minshew Magic wears off fast.

The glass shoe is not fitting so well for last week’s Cinderella team. Gardener Minshew was the talk of the N.F.L. in Week 1 when he completed 95 percent of his passes in the Jacksonville Jaguars’ shocking victory over Indianapolis, but he threw an interception on his first drive this week and his team is trailing the Tennessee Titans, 14-0, in the first quarter.

The Titans are rolling so far thanks to a familiar combination of strengths. Quarterback Ryan Tannehill hooked up with tight end Jonnu Smith for a 63-yard catch-and-run on the team’s first drive, and then got into the end zone with a 13-yard pass to Smith. Then, after Minshew’s interception, Tennessee capitalized by going 30 yards on five plays, with Tannehill throwing a 9-yard touchdown pass to Corey Davis. Derrick Henry, the team’s star running back, has been quiet so far with three carries for 8 yards.

Minshew, who only had one incompletion last week — and that was a drop — is just 2 for 6 so far.

The 49ers start with a touchdown.

It’s possible that the beginning of the Jets’ game Sunday could have gone worse. The San Francisco 49ers could have run the kickoff back for a touchdown. Instead, they scored on their first offensive play. Raheem Mostert took a pitch from Jimmy Garoppolo, zipped through a crease on the right side and sprinted down the sideline for an 80-yard touchdown. Mostert, the 49ers’ speedster who had four touchdowns in the N.F.C. championship game against Green Bay, had a 76-yard touchdown reception last week against Arizona.

It might be easier to say who isn’t hurt for San Francisco.

Health is a huge factor for sustained success, and with the luck the San Francisco 49ers have been having recently, it could be what puts them in an enormous hole in the N.F.C. West just a season after they made a trip to the Super Bowl.

Until shortly before Week 1, the 49ers believed they might have wide receiver Deebo Samuel back for the start of the season despite a broken foot sustained in June. Instead, the dynamic second-year player did not reach benchmarks the team set, and he was placed on this season’s unique three-game version of injured reserve.

San Francisco also began the season without starting center Weston Richburg, and in the team’s shocking loss at home to Arizona in Week 1, cornerback Richard Sherman injured his calf and joined Samuel on the injured reserve. In perhaps the biggest short-term blow, tight end George Kittle sprained his knee and will be out for this week, and potentially longer.

The 49ers are a talented team, with a enough depth to compete even with several stars sidelined — especially against the Jets. But with Seattle, Los Angeles and Arizona having each won their opening week games, and each having a solid chance at winning again this week, the pressure is suddenly on the 49ers to figure things out in a hurry.

Is it a Lambeau Leap if no one is there to catch you?

The Green Bay Packers won’t be playing in front of any fans at Lambeau Field, but that won’t stop running back Aaron Jones from making a Lambeau Leap — it just means there won’t be anyone to catch him.

“You’ll definitely still see a Lambeau Leap from me, probably right on one of those tarps,” Jones told reporters after practice on Friday.

Jones has reason to be confident he’ll score. The 25-year-old scored 19 touchdowns during the 2019 regular season, getting into the end zone at least once in 10 of his 16 games. In Green Bay’s Week 1 demolition of the Minnesota Vikings, Jones carried the ball 16 times for 66 yards, scoring on a 5-yard run in the fourth quarter.

George Kittle and Chris Godwin headline this week’s inactives.

Heading into the 1 p.m. games, there was good news and bad news for teams waiting for updates on their injured players.

In: The Miami Dolphins are bolstered by wide receiver DeVante Parker being cleared to play after injuring his hamstring in a Week 1 loss to New England. Parker had a quiet day against New England’s stellar secondary, and he has an equally difficult task this week against Buffalo’s terrific defense.

Wide receiver Golden Tate is active for the Giants after he missed the team’s loss to Pittsburgh with a hamstring injury.

Linebacker Khalil Mack of the Chicago Bears was able to get into last week’s surprising win over Detroit despite a knee injury, and he’s active again this week for Chicago’s matchup with the Giants.

Out: Tight end George Kittle will miss San Francisco’s game against the Jets as he works his way back from a sprained knee. Kittle was able to jog off the field at the time of the injury, and was practicing earlier in the week, but the team decided to rest him.

The Tampa Bay Buccaneers will be short at wide receiver with Chris Godwin ruled out as he works his way through the N.F.L.’s concussion protocol. His fellow star receiver, Mike Evans, will be active despite a hamstring injury.

The Denver Broncos will be without running back Philiip Lindsay, who is out with a toe injury. That should lead to an increased workload for Melvin Gordon.

The stellar offensive line of the Dallas Cowboys will be shorthanded with left tackle Tyron Smith sitting out with a neck injury. The team was already missing right tackle La’el Collins, who is on this season’s mini version of injured reserve..

Can any of last week’s Cinderellas get to 2-0?

A savvy observer might have been keeping an eye on the upstart Arizona Cardinals for a potential upset in Week 1, but no one saw the Washington Football Team or the Jacksonville Jaguars coming. Those teams were both predicted to be basement dwellers all season, but they got off to a terrific start by beating the Philadelphia Eagles and the Indianapolis Colts, respectively.

So … can they do it again?

The bad news for the Footballers is that they’re playing the Cardinals, and Arizona’s offensive line is not nearly as beat up as Philadelphia’s was. With Kyler Murray slinging balls all over the field to wide receives DeAndre Hopkins and Larry Fitzgerald, while also serving as a huge threat while running the ball, Washington could be in a lot of trouble.

The Jaguars, meanwhile, have to be thrilled with Gardner Minshew’s execution in a game in which he completed 95 percent of his passes while throwing three touchdown passes, but they might want to remember that they wouldn’t have beaten the Colts if not for Philip Rivers gift-wrapping them 14 points in the form of two interceptions. Expecting the Tennessee Titans to be so generous would not be wise.

The Vikings and the Colts would like to forget Week 1.

It was a truly ugly Week 1 for Minnesota’s defense, as the absence of the injured Danielle Hunter — and the team’s decision to jettison several stars — led to Green Bay doing just about anything it wanted. But hey, at least they didn’t lose to the Jacksonville Jaguars. The Indianapolis Colts would likely have preferred their destruction coming at the hands of Aaron Rodgers.

Today, Minnesota and Indianapolis will face off trying to erase any and all memories of last week’s failures. Barring a tie, one of these playoff hopefuls is about to begin the season with an 0-2 record.

Indianapolis is favored in the game, largely because Minnesota still has the same problems on defense it did a week ago. There also exists a fairly pervasive belief that the Colts simply can’t be that bad on offense or defense, even with running back Marlon Mack out for the season with a ruptured Achilles’ tendon. Jonathan Taylor was expected to take over for Mack at some point this season anyway, so this just moves up the timetable, and a defense that has Darius Leonard, Justin Houston and DeForest Buckner can typically be counted on to not be embarrassed.

Big wait for the big games

The 4 p.m. Eastern time games can sometimes seem like a chance to catch a break between the hectic early action, and the Sunday night game. That strategy won’t work today, as some of the best action is set to kick off at 4:25 p.m Eastern.

The Kansas City Chiefs are on the road facing the Los Angeles Chargers, a team that probably shouldn’t be expected to give Patrick Mahomes all that much trouble, but is far from a pushover. The Baltimore Ravens, meanwhile, are in Houston where Lamar Jackson and Deshaun Watson will face off in a battle of two of the best quarterbacks in the game — Watson, however, probably wishes he had Jackson’s teammates.

The good news is that the Sunday night game shouldn’t feel like that much of a letdown, as Cam Newton and the new-look New England Patriots are in Seattle to face Russell Wilson and the Seahawks. Between Newton’s running, Wilson’s overall brilliance, and the star-studded defenses on both teams, the nightcap could live up to its game of the week billing.